Publications

Dowdle ME & Lykke-Andersen J (2025) Cytoplasmic mRNA decay and quality control machineries in eukaryotes. Nat Rev Genet. [pubmed]

Ma T; Xiong ES; Lardelli RM; Lykke-Andersen J (2024) Sm complex assembly and 5′ cap trimethylation promote selective processing of snRNAs by the 3′ exonuclease TOE1. Proceedings of the National Academy of Sciences, 121(3): e2315259121 [pubmed]

Carreño A; & Lykke-Andersen J (2022) The Conserved CNOT1 Interaction Motif of Tristetraprolin Regulates ARE-mRNA Decay Independently of the p38 MAPK-MK2 Kinase Pathway. Mol. Cell. Biol. vol. 42 e00055-22 [pubmed]

Nicholson-Shaw T & Lykke-Andersen J (2022) Tailer: a pipeline for sequencing-based analysis of nonpolyadenylated RNA 3′ end processing. RNA, 28(5), 645-656. [pubmed]

Lardelli RM & Lykke-Andersen J (2020) Competition between maturation and degradation drives human snRNA 3′ end quality control. Genes Dev. 34(13-14), 989-1001. [pubmed]

Lardelli RM; Schaffer AE; Eggens VR; Zaki MS; Grainger S; Sathe S; Van Nostrand EL; Schlachetzki Z; Rosti B; Akizu N; Scott E; Silhavy JL; Heckman LD; Rosti RO; Dikoglu E; Gregor A; Guemez-Gamboa A; Musaev D; Mande R; Widjaja A; Shaw TL; Markmiller S; Marin-Valencia I; Davies JH; de Meirleir L; Kayserili H; Altunoglu U; Freckmann ML; Warwick L; Chitayat D; Blaser S; Çağlayan AO; Bilguvar K; Per H; Fagerberg C; Christesen HT; Kibaek M; Aldinger KA; Manchester D; Matsumoto N; Muramatsu K; Saitsu H; Shiina M; Ogata K; Foulds N; Dobyns WB; Chi NC; Traver D; Spaccini L; Bova SM; Gabriel SB; Gunel M; Valente EM; Nassogne MC; Bennett EJ; Yeo GW; Baas F; Lykke-Andersen J; Gleeson JG (2017) Biallelic mutations in the 3′ exonuclease TOE1 cause pontocerebellar hypoplasia and uncover a role in snRNA processing. Nat. Genet. 49(3), 457-464. [pubmed]

Durand S; Franks TM; Lykke-Andersen J (2016) Hyperphosphorylation amplifies UPF1 activity to resolve stalls in nonsense-mediated mRNA decay. Nat Commun 7:12434-None [pubmed]

Arribas-Layton M; Dennis J; Bennett EJ; Damgaard CK; Lykke-Andersen J (2016) The C-Terminal RGG Domain of Human Lsm4 Promotes Processing Body Formation Stimulated by Arginine Dimethylation. Mol. Cell. Biol. 36:2226-2235 [pubmed]

Fu R; Olsen MT; Webb K; Bennett EJ; Lykke-Andersen J (2016) Recruitment of the 4EHP-GYF2 cap-binding complex to tetraproline motifs of tristetraprolin promotes repression and degradation of mRNAs with AU-rich elements. RNA 22:373-382 [pubmed]

Toma KG; Rebbapragada I; Durand S; Lykke-Andersen J (2015) Identification of elements in human long 3′ UTRs that inhibit nonsense-mediated decay. RNA 21:887-897 [pubmed]

Lee SR; Pratt GA; Martinez FJ; Yeo GW; Lykke-Andersen J (2015) Target Discrimination in Nonsense-Mediated mRNA Decay Requires Upf1 ATPase Activity. Mol. Cell 59:413-425 [pubmed]

Erickson SL; Corpuz EO; Maloy JP; Fillman C; Webb K; Bennett EJ; Lykke-Andersen J (2015) Competition between Decapping Complex Formation and Ubiquitin-Mediated Proteasomal Degradation Controls Human Dcp2 Decapping Activity. Mol. Cell. Biol. 35:2144-2153 [pubmed]

Lykke-Andersen J; Bennett EJ (2014) Protecting the proteome: Eukaryotic cotranslational quality control pathways. J. Cell Biol. 204:467-476 [pubmed]

Reznik B; Clement SL; Lykke-Andersen J (2014) hnRNP F complexes with tristetraprolin and stimulates ARE-mRNA decay. PLoS ONE 9:e100992-None [pubmed]

Arribas-Layton M; Wu D; Lykke-Andersen J; Song H (2013) Structural and functional control of the eukaryotic mRNA decapping machinery. Biochim. Biophys. Acta 1829:580-589 [pubmed]

Durand S; Lykke-Andersen J (2013) Nonsense-mediated mRNA decay occurs during eIF4F-dependent translation in human cells. Nat. Struct. Mol. Biol. 20:702-709 [pubmed]

Lee SR; Lykke-Andersen J (2013) Emerging roles for ribonucleoprotein modification and remodeling in controlling RNA fate. Trends Cell Biol. 23:504-510 [pubmed]

Damgaard CK; Lykke-Andersen J (2013) Regulation of ARE-mRNA Stability by Cellular Signaling: Implications for Human Cancer. Cancer Treat. Res. 158:153-180 [pubmed]

Erickson SL; Lykke-Andersen J (2011) Cytoplasmic mRNP granules at a glance. J. Cell. Sci. 124:293-297 [pubmed]

Clement SL; Scheckel C; Stoecklin G; Lykke-Andersen J (2011) Phosphorylation of tristetraprolin by MK2 impairs AU-rich element mRNA decay by preventing deadenylase recruitment. Mol. Cell. Biol. 31:256-266 [pubmed]

Durand S; Lykke-Andersen J (2011) SnapShot: Nonsense-mediated mRNA decay. Cell 145:324-324.e2 [pubmed]

Damgaard CK; Lykke-Andersen J (2011) Translational coregulation of 5’TOP mRNAs by TIA-1 and TIAR. Genes Dev. 25:2057-2068 [pubmed]

Franks TM; Singh G; Lykke-Andersen J (2010) Upf1 ATPase-dependent mRNP disassembly is required for completion of nonsense- mediated mRNA decay. Cell 143:938-950 [pubmed]

Reznik B; Lykke-Andersen J (2010) Regulated and quality-control mRNA turnover pathways in eukaryotes. Biochem. Soc. Trans. 38:1506-1510 [pubmed]

Rebbapragada I; Lykke-Andersen J (2009) Execution of nonsense-mediated mRNA decay: what defines a substrate? Curr. Opin. Cell Biol. 21:394-402 [pubmed]

Clement SL; Lykke-Andersen J (2008) A tethering approach to study proteins that activate mRNA turnover in human cells. Methods Mol. Biol. 419:121-133 [pubmed]

Singh G; Rebbapragada I; Lykke-Andersen J (2008) A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay. PLoS Biol. 6:e111-None [pubmed]

Wagner E; Clement SL; Lykke-Andersen J (2007) An unconventional human Ccr4-Caf1 deadenylase complex in nuclear cajal bodies. Mol. Cell. Biol. 27:1686-1695 [pubmed]

Franks TM; Lykke-Andersen J (2007) TTP and BRF proteins nucleate processing body formation to silence mRNAs with AU-rich elements. Genes Dev. 21:719-735 [pubmed]

Singh G; Jakob S; Kleedehn MG; Lykke-Andersen J (2007) Communication with the exon-junction complex and activation of nonsense-mediated decay by human Upf proteins occur in the cytoplasm. Mol. Cell 27:780-792 [pubmed]

Clement SL; Lykke-Andersen J (2006) No mercy for messages that mess with the ribosome. Nat. Struct. Mol. Biol. 13:299-301 [pubmed]

Fillman C; Lykke-Andersen J (2005) RNA decapping inside and outside of processing bodies. Curr. Opin. Cell Biol. 17:326-331 [pubmed]

Weischenfeldt J; Lykke-Andersen J; Porse B (2005) Messenger RNA surveillance: neutralizing natural nonsense. Curr. Biol. 15:R559-62 [pubmed]

Lykke-Andersen J; Wagner E (2005) Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1. Genes Dev. 19:351-361 [pubmed]

Kedersha N; Stoecklin G; Ayodele M; Yacono P; Lykke-Andersen J; Fritzler MJ; Scheuner D; Kaufman RJ; Golan DE; Anderson P (2005) Stress granules and processing bodies are dynamically linked sites of mRNP remodeling. J. Cell Biol. 169:871-884 [pubmed]

Fenger-Grøn M; Fillman C; Norrild B; Lykke-Andersen J (2005) Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping. Mol. Cell 20:905-915 [pubmed]

Lykke-Andersen J (2004) Making structural sense of nonsense-mediated decay. Nat. Struct. Mol. Biol. 11:305-306 [pubmed]

Singh G; Lykke-Andersen J (2003) New insights into the formation of active nonsense-mediated decay complexes. Trends Biochem. Sci. 28:464-466 [pubmed]

Wagner E; Lykke-Andersen J (2002) mRNA surveillance: the perfect persist. J. Cell. Sci. 115:3033-3038 [pubmed]

Lykke-Andersen J (2002) Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay. Mol. Cell. Biol. 22:8114-8121 [pubmed]

Lykke-Andersen J (2001) mRNA quality control: Marking the message for life or death. Curr. Biol. 11:88-91 [pubmed]

Lykke-Andersen J; Shu MD; Steitz JA (2001) Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1. Science 293:1836-1839 [pubmed]

Lykke-Andersen J; Shu MD; Steitz JA (2000) Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon. Cell 103:1121-1131 [pubmed]